Missouri MLB Betting Guide: How to Bet on MLB in MO

How to Bet on MLB in Missouri

If you're brand new to sports betting, the following breakdown will help you learn the ropes so you're ready to place your first MLB wager in Missouri when the time comes. For those with sports betting experience, it's a solid refresher that offers useful insights into how MLB betting works in the state. 

With Missouri home to two MLB teams, the St. Louis Cardinals and Kansas City Royals, interest in baseball betting is already strong across the state. And with 162 regular-season games per team, MLB offers more betting opportunities than almost any other major sport.

1. Download An App

Before you can place a bet, you first have to figure out which sportsbook app you want to use. With the potential for up to 14 MO betting apps, this may seem like a daunting task. For the most part, every operator will have the basics covered when it comes to betting on the MLB in Missouri. As long as you're using a legal and licensed site, you really can't go wrong.

Which app you use will come down to personal preference. I always recommend signing up with multiple sportsbooks so you can compare odds before placing any wagers. Getting the best price means a better potential payout, and that can add up over time. Here are a few of my favorite things about the operators we expect to be available in Missouri:

• DraftKings MO - Best for player props and overall market variety
• FanDuel MO - Best for beginners
• Caesars MO - Best for odds boosts
• BetMGM MO - Best for localized experience
• bet365 MO - Best for early payouts
• Fanatics Sportsbook MO - Best for rewards program

This can serve as a solid starting point, but it’s a good idea to download each app and spend a few minutes exploring to see which one feels right for you. Most sportsbooks let you browse their platform without creating an account first.

2. Claim Your Welcome Offer

If this is your first time signing up for a particular operator, you'll be able to claim new user Missouri sportsbook promos. While this isn't required, there is generally no reason not to take advantage of these bonuses.

Once these offers are officially available, we'll provide exclusive codes and links so you can get the most out of your betting experience. This will include things like bonus bets, bet matches, and more.

3. Find the Bet You Want to Place

As mentioned above, different operators offer varying levels of market depth across each sport, and MLB is no exception. Below is a list of the most popular types of MLB wagers, along with a brief explanation of how each one works:

• Moneyline: The most straightforward type of bet. You’re simply picking which team will win the game.
• Run Line: This is baseball’s version of a point spread. The run line is usually set at 1.5. If the Cardinals are -1.5, they need to win by 2 or more runs for your bet to hit. If they’re +1.5, they can lose by 1 run (or win outright), and your bet still wins.
• Totals (Over/Under): A wager on the total number of combined runs scored by both teams. If the total is set at 6.5, the over hits with 7 or more runs, while the under wins with 6 or fewer.
• Parlays: A parlay combines two or more bets (called “legs”) into a single wager. Parlays offer bigger payouts, but every leg must win for the ticket to cash. For example, if you build a 4-leg parlay, all four bets must hit.
• Props: MLB prop bets can focus on teams or individual players. Examples include the total number of strikeouts by the Cardinals or betting on whether Bobby Witt Jr. will hit a home run.

4. Determine Your Bet Size

While this step is often overlooked, it's one of the most important things you can do as a bettor. Your deposit size should guide how much you're wagering, not the other way around. Setting clear limits and sticking to them helps you manage your bankroll, avoid chasing losses, and make smarter betting decisions over time.

A well-managed bankroll can extend your betting activity and help you spot value more clearly,  since you're betting with intention, not emotion.

Popular MLB Odds in MO

Here are a few popular MLB betting markets to watch as we enjoy the offseason, including who will win the World Series. All of the odds listed are from top sportsbooks including bet365 Missouri.

2026 Futures Odds

 

MLB Teams in Missouri

If you’re looking to bet on MLB teams in Missouri, you’ll be happy to know the Show-Me State is home to two pro clubs: the Kansas City Royals and the St. Louis Cardinals. The Royals last won the World Series in 2015, while the Cardinals’ most recent title came in 2011. Both teams entered 2025 as long shots to win it all, with the Dodgers ultimately taking the title again.

Kansas City Royals

The Kansas City Royals have seen a resurgence lately, thanks in large part to the breakout of star shortstop Bobby Witt Jr. Kansas City made a surprise run to the playoffs in the 2024 MLB season but fell short in the Wild Card round against the New York Yankees. Even with a young and improving roster, the Royals’ failed to make the playoffs in the 2025 season. Make sure to follow along next season as we follow the Royals playoff chances.

St. Louis Cardinals

The St. Louis Cardinals hold the second-most World Series titles in MLB history, trailing only the New York Yankees. But recent seasons haven’t lived up to that legacy. After missing the playoffs in 2024 and struggling with consistency, there’s not much buzz around St. Louis failed to advance to the postseason in 2025. Follow along next season as the team gets back on track in pursuit of another playoff berth with our Cardinals playoff chances page.