Betting on the Chiefs in MO: A Step-by-Step Guide
Sports betting is coming soon to Missouri, and it’s worth knowing what to look for before placing your first NFL bets, especially on the hometown favorite, the Chiefs. With the launch set for December 1, 2025, this guide serves as your playbook for making smarter wagers.
Pick An App
The first thing you have to do before placing any NFL or Chiefs bets is to decide which sportsbook you want to use. Luckily for you, you can check out our Missouri betting apps page, as well as individual brand reviews to figure out which operator(s) you want to go with.
If you plan on placing standard wagers like moneylines and spreads, the main difference between betting sites will be the odds of each market. If you want to dig a little deeper and place other types of bets like player props, doing your homework is worthwhile. Most sportsbooks will provide a variety of odds for the NFL season. The 2025-26 season kicks off on September 4 with the Philadelphia Eagles hosting the Dallas Cowboys on Thursday Night Football. The next night, the Kansas City Chiefs take the field in Brazil for a divisional showdown against the Los Angeles Chargers.
Choose Your Wager
Because NFL betting is by far the most popular option across the US, you'll find some of the most expansive markets for football compared to other sports. Here are some of the most common bet types:
- Moneyline
- Spread
- Totals
- Parlays
- Prop bets
- Live betting
Before placing any wager, whether it's on the Chiefs, another NFL team, or a different sport altogether, be sure you understand how that market works. Moneylines are the most straightforward bet there is, while spread betting can be confusing to some at first.
For beginners, it’s wise to approach parlays with caution. While the idea of turning $5 into $5,000 is tempting, parlays are designed to be tough to hit, and that’s why sportsbooks profit the most from them and promote them heavily.
When Missouri sports betting launches, you can bet futures such as the Chiefs playoff odds, Chiefs AFC Championship odds, Chiefs Super Bowl odds, and more.
What Are the Chiefs' Playoff Chances in 2025?
Here's a quick look at the Chiefs' odds to make the playoffs, along with additional betting-related markets at DraftKings Sportsbook. Keep in mind, these are early numbers, odds will shift once the season gets underway and can vary depending on the sportsbook.
| 🔥 Chiefs Playoff Chances | 77.8% (-350) |
| 🏆 Chiefs Chances to Win Super Bowl LX | 10.5% (+850) |
| 👑 Chiefs Chances to Win AFC | 20.0% (+400) |
| 🥇 Chiefs Chances to Win AFC West | 53.5% (-115) |
| ⭐️ Patrick Mahomes Chances to Win MVP | 12.5% (+700) |
| 📆 Odds Last Verified | August 2025 |
Choose Your Wager Amount
This is arguably the most important part of the process. When sizing your bets, the key advice is to choose an amount you’re comfortable losing and stick to it. Before placing any bet, imagine the money is already gone. If that thought makes you uneasy or unsure, it’s a sign to lower your wager.
Many sportsbooks also offer responsible gambling tools, like personalized settings where you can preset your bet amount. That way, when you’re ready, all you have to do is hit "Place Bet," helping you stay in control and avoid overspending.
MORE: Chiefs Super Bowl Odds
Author
Cody Kutzer has been covering the sports betting and gambling space for several years and has been losing his parlay bets for even longer. He currently serves as an editor, writer, and fact-checker for BetMissouri.com to ensure readers have the latest and most accurate information surrounding sports betting in the state.
